There has been a dramatic increase in the worldwide prevalenceof obesity, a disorder with complex genetic traits that is influencedby environmental factors and that predisposes affected personsto diseases such as diabetes mellitus, hypertension, stroke,and heart attack. Since it has arisen with the increasing availabilityof easily obtainable calories, this pandemic of obesity is oftenascribed to gluttony. If energy balance is taken into account,however, eating behavior can be viewed as controlled by homeostaticmechanisms whereby hormonal signals from adipose tissue providefeedback to neural circuitry to regulate appetite. From thisperspective, most weight gain represents . . . [Full Text of this Article]
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From the Laboratory of Molecular Endocrinology, Massachusetts General Hospital, Boston.
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