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Volume 348:1176-1177 March 20, 2003 Number 12
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Risk of Myocardial Infarction and Polymorphisms in Candidate Genes

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by Yamada, Y.
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To the Editor: Yamada et al. (Dec. 12 issue)1 state that the identification of genotypes of the 4G–668/5G polymorphism of the gene encoding plasminogen-activator inhibitor type 1 may be a reliable means of predicting the risk of myocardial infarction in women. We performed a matched case–control study of the polymorphism in 298 Italian women, half of whom had had a first myocardial infarction before the age of 45 years; the others were healthy members of the hospital staff. This population was chosen because there is usually little coronary atherosclerosis among premenopausal women, in whom it is therefore biologically plausible that . . . [Full Text of this Article]



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