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Editorial
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Volume 348:1277-1278 March 27, 2003 Number 13
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"Silent" Strokes and Dementia
John P. Blass, M.D., Ph.D., and Rajiv R. Ratan, M.D., Ph.D.

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-Related Article
 by Vermeer, S. E.
-PubMed Citation
An epidemiologic study by Vermeer et al. in this issue of the Journal indicates that "silent" strokes are a risk factor for dementia.1 Recurrent strokes during the three to four years of follow-up in this study appear to have been the mechanism of — or at least a marker for — cognitive decline. The presence of the apolipoprotein E {epsilon}4 allele did not account for the relation between stroke and dementia, although that allele is known to be a risk factor for both Alzheimer's disease and vascular disease. These observations are intuitively attractive; stroke can impair brain function, including cognition. . . . [Full Text of this Article]


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From the Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, N.Y.


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