Infection with Vancomycin-Resistant Staphylococcus aureus Containing the vanA Resistance Gene
Soju Chang, M.D., M.P.H., Dawn M. Sievert, M.S., Jeffrey C. Hageman, M.H.S., Matthew L. Boulton, M.D., Fred C. Tenover, Ph.D., M.P.H., Frances Pouch Downes, Dr.P.H., Sandip Shah, M.S., James T. Rudrik, Ph.D., Guy R. Pupp, D.P.M., William J. Brown, Ph.D., Denise Cardo, M.D., Scott K. Fridkin, M.D., for the Vancomycin-Resistant Staphylococcus aureus Investigative Team
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Until recently, vancomycin was the only uniformly effectivetreatment for staphylococcal infections. In 1997, the firstclinical isolate of Staphylococcus aureus with reduced susceptibilityto vancomycin was reported,1 and as of June 2002, eight confirmedinfections with such strains had been reported in patients inthe United States.2,3,4,5,6 The minimal inhibitory concentrations(MICs) of vancomycin reported for these isolates are in theintermediate range (8 to 16 µg per milliliter) accordingto interpretive criteria defined by the National Committee forClinical Laboratory Standards.7
In June 2002, a clinical isolate of vancomycin-resistant S.aureus (VRSA) (MIC, >32 µg per milliliter) was . . . [Full Text of this Article]
Case Report
Methods
Results
Epidemiologic Studies
Laboratory Studies
Discussion
Source Information
From the Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office (S.C.), and the Division of Healthcare Quality Promotion, National Center for Infectious Diseases (J.C.H., F.C.T., D.C., S.K.F.), Centers for Disease Control and Prevention, Atlanta; the Bureau of Epidemiology (D.M.S., M.L.B.) and the Bureau of Laboratories (F.P.D., S.S., J.T.R.), Michigan Department of Community Health, Lansing; Lakeview Podiatry Associates, Dearborn, Mich. (G.R.P.); and the Department of Pathology, Wayne State University School of Medicine and Detroit Medical Center University Laboratories, Detroit (W.J.B.).
Address reprint requests to Dr. Fridkin at the Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop A-35, Atlanta, GA 30333, or at sfridkin@cdc.gov.
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