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Previous Volume 348:1356-1364 April 3, 2003 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The incidence of many common diseases is increased among the relatives of affected patients, but the pattern of inheritance rarely follows Mendel's laws. Instead, such common diseases are thought to result from a complex interaction among multiple predisposing genes and other factors, including environmental contributions and chance occurrences. Identifying the genetic contribution to such complex diseases is a major challenge for genomic medicine. However, as so clearly foreseen nearly 350 years ago by the English physiologist William Harvey,¹ finding the genetic basis for rarer, mendelian forms of a disease may illuminate the etiologic process and pathogenesis of the more common, . . . [Full Text of this Article]

Alzheimer's Disease

Parkinson's Disease

Conclusions

Source Information

From the Genetic Diseases Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Md.

Address reprint requests to Dr. Nussbaum at the Genetic Diseases Research Branch, National Human Genome Research Institute, NIH, 49 Convent Dr., Rm. 4A72, Bethesda, MD 20892-4472, or at rlnuss@nhgri.nih.gov.

Related Letters:

Genetics of Neurodegenerative Disorders
Caruso C., Franceschi C., Licastro F., Nussbaum R., Ellis C.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:193-194, Jul 10, 2003. Correspondence

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