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Previous Volume 348:1483-1485 April 10, 2003 Number 15 Next

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Nitric oxide is a highly reactive molecule with many biologic effects. Its function as the "endothelium-derived relaxing factor" that regulates vascular tone is a central feature of its role as a signaling molecule. Endothelial cells use arginine to produce nitric oxide gas, which diffuses into the surrounding smooth muscle, where it induces relaxation of vascular smooth muscle and dilatation of blood vessels (Figure 1).

View larger version (52K): [in this window] [in a new window]   Figure 1. A Model of the Interactions of Nitric Oxide (NO) with Erythrocytes and Cell-free Hemoglobin in an Arterial Blood Vessel. The diagram illustrates the major processes regulating nitric oxide levels in blood vessels during pharmacologic . . . [Full Text of this Article]

 

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From the Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases, and the Critical Care Medicine Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Md.

Address reprint requests to Dr. Schechter at the Laboratory of Chemical Biology, NIDDK, Bldg. 10, Rm. 9N-307, National Institutes of Health, Bethesda, MD 20892-1822, or at aschecht@helix.nih.gov.

Related Letters:

Hemoglobin and Nitric Oxide
Stamler J. S., Gaston B. M., Hare J. M., McMahon T. J., Pawloski J. R., Singel D. J., Schechter A. N., Gladwin M. T.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:402-405, Jul 24, 2003. Correspondence

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