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Previous Volume 348:1587-1589 April 17, 2003 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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On the day I was asked to write this editorial, my 80-year-old father had a nearly fatal adverse drug event. His physicians had attributed the nonspecific symptoms to his Parkinson's disease and had increased his dose of levodopa–carbidopa. His physical and cognitive function continued to worsen, until hallucinations, chorioform movements, and blepharospasm characteristic of levodopa–carbidopa toxicity developed and he became bedridden. The drug was stopped, and his condition improved dramatically over the ensuing 48 hours; he became ambulatory and regained his base-line mental status. This incident had many of the typical features of adverse drug events. It involved an elderly . . . [Full Text of this Article]

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From the Division of General Internal Medicine and Geriatrics, Department of Medicine, Indiana University School of Medicine, and the Regenstrief Institute — both in Indianapolis.

Related Letters:

Adverse Drug Events in Ambulatory Care
Hernández J., Vargas M. L., Snow D., Gandhi T. K., Weingart S. N., Bates D. W., Tierney W. M.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:303-305, Jul 17, 2003. Correspondence

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