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Previous Volume 348:1598-1599 April 17, 2003 Number 16 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: As participants in the original exploratory study,¹ we did not find that treatment with anti–₄ integrin antibody was of clinical benefit. Miller and colleagues ( Jan. 2 issue)² report that monthly natalizumab infusions in patients with multiple sclerosis significantly reduced relapse rates and enhancing lesions on magnetic resonance imaging (MRI), but this effect was not carried forward in the six months after treatment. The treatment had no effect on the disability score (on the Kurtzke Expanded Disability Status Scale). There was no evidence that long-term natalizumab infusions modify the course of multiple sclerosis.

Epidemiologic studies have shown . . . [Full Text of this Article]

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