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Volume 348:1600-1602 April 17, 2003 Number 16
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Sepsis — Theory and Therapies

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by Hotchkiss, R. S.
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To the Editor: Hotchkiss and Karl (Jan. 9 issue)1 rightly stress the complex nature of the interaction between circulating proinflammatory and antiinflammatory factors and emphasize the importance of the immunologic depression that ensues. However, in their evaluation of potential therapies, they neglect to mention the role of extracorporeal blood-purification techniques, which have been shown to reduce mortality and attenuate shock in experimental models of sepsis. Unlike experimental antibody therapies, hemofiltration has already been used effectively in the treatment of sepsis in humans with concomitant shock, multiorgan failure, or both and in those without these conditions.2,3 Furthermore, other randomized, controlled studies . . . [Full Text of this Article]



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