Laboratory investigators have long known that animals in whichenergy intake is reduced to about 60 percent of the intake ofanimals that are fed as much as they want have a considerablylower incidence of cancer than the control animals. This findingapparently holds true for viral, chemical, and even spontaneouscarcinogenesis. Evidence from studies in humans has been largelycompatible with these laboratory findings and is applicableto a wide spectrum of sites and types of tumors. Yet this evidencehas not stimulated the development of programs to prevent cancerby weight control.
From the Department of Medical Epidemiology, Karolinska Institutet, Stockholm, Sweden (H.-O.A.), and the Department of Epidemiology, Harvard School of Public Health, Boston (D.T.).
Related Letters:
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Deutsch M. E., Flegal K. M., Williamson D. F., Graubard B. I., Frankel P. H., Gaesser G. A., Smith J. A., Calle E. E., Rodriguez C., Thun M. J.
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N Engl J Med 2003;
349:502-504, Jul 31, 2003.
Correspondence
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