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Previous Volume 348:1692-1701 April 24, 2003 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Presentation of Case

A 14-month-old boy was admitted to the hospital because of hepatomegaly, left-sided ptosis, and a bony lump on the forehead.

The patient had been constipated for several months, passing one hard stool every two or three days with pain. Three months before admission, fevers began; his temperature rose as high as 39.4°C for two to three days. About two months before admission, intermittent sweats occurred, as did fevers, with temperatures that seldom exceeded 37.8°C. About two months before admission, the patient was noted to have a perianal rash. A dermatologist prescribed a series of topical treatments that included bacitracin, mupirocin, . . . [Full Text of this Article]

Differential Diagnosis

Orbital Infections

Sarcoidosis

Small, Round, Blue-Cell Tumors of Childhood

            Rhabdomyosarcoma

            Neuroblastoma

            Lymphomas

            Acute Myeloid Leukemia

Childhood Histiocytic Disorders

            Langerhans'-Cell Histiocytosis

            Hemophagocytic Histiocytic Disorders

            Sinus Histiocytosis with Massive Lymphadenopathy (Rosai–Dorfman Disease)

            Malignant Histiocytosis

Summary

Clinical Diagnosis

Dr. G. Naheed Usmani's Diagnosis

Pathological Discussion

Anatomical Diagnosis

Addendum

Source Information

From the Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Massachusetts Medical School, and Children's Medical Center, UMass Memorial Healthcare — both in Worcester, Mass. (G.N.U.); and the Departments of Radiology (S.J.W.) and Pathology (S.Y.), Massachusetts General Hospital and Harvard Medical School — both in Boston.

This article has been cited by other articles:

• Hait, E., Liang, M., Degar, B., Glickman, J., Fox, V. L. (2006). Gastrointestinal Tract Involvement in Langerhans Cell Histiocytosis: Case Report and Literature Review. Pediatrics 118: e1593-e1599 [Abstract] [Full Text]  
• Walter, J. E., Miller, J., Fisher, R. G., Byrd, R. (2006). Subcutaneous Nodule in a Young Girl: A Diagnostic Dilemma. CLIN PEDIATR 45: 661-664  
• Ghia, K. K., Chen, Y., Milner, D. A. Jr, Fisher, D. C. (2004). Challenging Manifestations of Malignancies: CASE 2. Langerhans Cell Histiocytosis Presenting With a Skin Rash. JCO 22: 3640-3642 [Full Text]