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Previous Volume 348:1709-1711 April 24, 2003 Number 17 Next

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Rheumatoid arthritis is a chronic destructive disease of joints, characterized by inflammation, synovial hyperplasia, and abnormal cellular and humoral immune responses. Although several types of cells have been proposed to trigger synovial inflammation, the etiologic process and pathogenesis of the disease remain controversial. But, as indicated by a recent study by Lee et al.,¹ the mast cell is emerging as a key player in the erosive and inflammatory events leading to joint destruction (Figure 1).

View larger version (83K): [in this window] [in a new window]   Figure 1. The Mighty Mast Cell. A recent study by Lee et al.1 demonstrated a key role of mast cells in mediating events that lead . . . [Full Text of this Article]

 

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From the University Department of Medicine, Manchester Royal Infirmary, Manchester, United Kingdom.

Related Letters:

Mast Cells and the Mediation of T-Cell Recruitment in Arthritis
Askenase P. W.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:1294, Sep 25, 2003. Correspondence

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