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Previous Volume 348:1777-1785 May 1, 2003 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The diagnosis of the hematologic cancers presents a daunting challenge. The many stages of normal hematopoietic differentiation give rise to a number of biologically and clinically distinct cancers. Inherited DNA-sequence variants do not appear to have a prominent causative role; rather, these diverse cancers are typically initiated by acquired alterations to the genome of the cancer cell, such as chromosomal translocations, mutations, and deletions. The diagnosis of the hematologic cancers is commonly based on morphologic evaluation supplemented by analysis of a few molecular markers. However, in some diagnostic categories defined in this fashion, the response of patients to treatment is . . . [Full Text of this Article]

Molecular Diagnosis of Non-Hodgkin's Lymphoma

Diffuse Large-B-Cell Lymphoma

Predicting the Clinical Outcome

Molecular Diagnosis of Leukemias

Acute Leukemias

Chronic Lymphocytic Leukemia

Translating Molecular Diagnosis into a Clinical Reality

Source Information

From the Metabolism Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Md.

Address reprint requests to Dr. Staudt at the Metabolism Branch, NCI, Bldg. 10, Rm. 4N114, NIH, 9000 Rockville Pike, Bethesda, MD 20892, or at lstaudt@mail.nih.gov.

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