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Volume 348:1810-1812 May 1, 2003 Number 18
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Environmental Lead Exposure and Chronic Renal Disease

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by Lin, J.-L.
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To the Editor: Lin et al. (Jan. 23 issue)1 implicate lead exposure in the progression of renal disease on the basis of the effect of EDTA chelation. However, there are compelling experimental data implicating iron (mobilized from endogenous sources and participating in free-radical reactions) in a wide variety of immune and nonimmune glomerular diseases,2 as well as models of progressive kidney diseases.3 This evidence includes an increase in catalytic iron and the beneficial effect of iron chelators, an iron-deficient diet, or both.2,3 The affinity constants of complexes of EDTA with Fe2+, Fe3+, Pb2+ are 14.3, 25.1, and 18.0 . . . [Full Text of this Article]



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