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Previous Volume 348:1917-1919 May 8, 2003 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In the search for genes that are relevant to disease, new contexts are discovered for "old" molecules. Several genes are particularly versatile, in that they are individually responsible for more than one disease. A study by Howlett et al.¹ provides an interesting example: mutation of BRCA2, a breast-cancer–susceptibility gene, may cause Fanconi's anemia. The discovery that a single gene can be mutated in two diseases involving genomic instability provides fascinating new insights into carcinogenesis and, potentially, cancer therapy.

The human genome is typically so stable that the many genetic alterations required for cancer to develop cannot accumulate unless the rate . . . [Full Text of this Article]

Source Information

From the University of Cambridge, Cancer Research United Kingdom Department of Oncology, Medical Research Council Cancer Cell Unit, Cambridge, United Kingdom.

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