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Previous Volume 348:1931-1932 May 8, 2003 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The clinical problem that was easy to see (Jan. 2 issue)¹ could have been less hard to find if the diagnostic approach had been slightly different. When myeloma is likely, the first step should be to look for a paraprotein. Serum and an aliquot from a 24-hour urine collection should be subjected to immunofixation because small quantities of paraprotein may be missed on gel electrophoresis² and because analysis of a random urine sample may not reveal paraprotein. A new serum free-light-chain assay may detect paraprotein in instances in which the results of immunofixation are negative.³

Marrow infiltration . . . [Full Text of this Article]

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