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Volume 348:174-175 January 9, 2003 Number 2
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Mammographic Density of the Breast

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 by Thurfjell, E.
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 by Boyd, N. F.
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To the Editor: Boyd et al. (Sept. 19 issue)1 estimated that the heritability of mammographic density was 60 percent among Australian twins and 67 percent among American twins. Although twin studies reveal little about the mode of inheritance, we previously reported a segregation analysis of 258 multigenerational families that provided evidence of a common major gene (6 percent frequency) that was transmitted in a mendelian fashion.2 Stronger evidence of a genetic influence was subsequently published in the form of a linkage analysis involving pairs of siblings, which used information from DNA analysis, mammographic information, and data on covariates to identify . . . [Full Text of this Article]




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