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Correspondence
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Volume 348:178-179 January 9, 2003 Number 2
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Hepatitis C Virus, Human Herpesvirus 8, and the Development of Plasma-Cell Leukemia

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To the Editor: The role of hepatitis C virus (HCV) and human herpesvirus 8 (HHV-8), two B-cell–tropic viruses, in B-cell proliferation1 is illustrated by the following unusual case of plasma-cell leukemia. In 1995, a 32-year-old man with a history of hepatitis A virus and HCV infection but who tested negative for hepatitis B virus and human immunodeficiency virus was admitted to the hospital with septic shock, bilateral pneumonia, and hepatosplenomegaly. The hemoglobin level was 8.9 g per deciliter; the white-cell count was 26.6x109 per liter with 50 percent plasmablasts (Figure 1A), 41 percent neutrophils, 7 percent . . . [Full Text of this Article]



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