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Volume 348:2055-2056 May 22, 2003 Number 21 Next

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The National Emphysema Treatment Trial (NETT), reported in this issue of the Journal (pages 2059–2073) raises interesting questions about the interpretation of secondary analyses of data collected in clinical trials. After exclusion of 140 patients with a high risk of death from surgery according to an interim analysis,¹ the 538 patients who were randomly assigned to surgery were more likely than the 540 assigned to medical therapy to have improvements in exercise capacity and quality of life, but there was no reduction in mortality during an average of 29 months of follow-up.

In the secondary analyses, however, the effects of . . . [Full Text of this Article]

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This article was published at www.nejm.org on May 20, 2003.

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