Successful Cardiac Transplantation in an HIV-1Infected Patient with Advanced Disease
Leonard H. Calabrese, D.O., Mary Albrecht, M.D., James Young, M.D., Patrick McCarthy, M.D., Marcus Haug, Pharm.D., John Jarcho, M.D., and Robert Zackin, Sc.D.
Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.
Advances in the management of human immunodeficiency virus (HIV)infection specifically, the introduction of highly activeantiretroviral therapy have dramatically delayed theprogression of disease, enhanced immunologic function, and reducedmortality.1 Coincident with these trends has been an increasein mortality due to end-organ failure, rather than from otherlife-threatening causes related to HIV.2 Therapy for end-organfailure has generally been supportive, but during the past fewyears, a small number of solid-organ transplantations, mostlyof kidneys and livers, in patients known to be HIV-positivehave been reported.3,4,5 Recently, on both ethical and scientificgrounds, some have called . . . [Full Text of this Article]
Case Report
Results
Clinical Course after Transplantation
Pharmacokinetics
Discussion
Source Information
From the Departments of Rheumatology and Immunology (L.H.C.), Cardiology (J.Y.), Cardiothoracic Surgery (P.M.), and Pharmacy (M.H.), Cleveland Clinic Foundation, Cleveland; the Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston (M.A.); the Cardiovascular Division, Brigham and Women's Hospital, Boston (J.J.); and the Harvard School of Public Health, Boston (R.Z.).
Address reprint requests to Dr. Calabrese at the Cleveland Clinic Foundation, 9500 Euclid Ave., Desk A-50, Cleveland, OH 44195, or at calabrl@ccf.org.
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