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Original Article
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Volume 348:2323-2328 June 5, 2003 Number 23
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Successful Cardiac Transplantation in an HIV-1–Infected Patient with Advanced Disease
Leonard H. Calabrese, D.O., Mary Albrecht, M.D., James Young, M.D., Patrick McCarthy, M.D., Marcus Haug, Pharm.D., John Jarcho, M.D., and Robert Zackin, Sc.D.

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 by Roland, M. E.
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Advances in the management of human immunodeficiency virus (HIV) infection — specifically, the introduction of highly active antiretroviral therapy — have dramatically delayed the progression of disease, enhanced immunologic function, and reduced mortality.1 Coincident with these trends has been an increase in mortality due to end-organ failure, rather than from other life-threatening causes related to HIV.2 Therapy for end-organ failure has generally been supportive, but during the past few years, a small number of solid-organ transplantations, mostly of kidneys and livers, in patients known to be HIV-positive have been reported.3,4,5 Recently, on both ethical and scientific grounds, some have called . . . [Full Text of this Article]

Case Report

Results

Clinical Course after Transplantation

Pharmacokinetics

Discussion


Source Information

From the Departments of Rheumatology and Immunology (L.H.C.), Cardiology (J.Y.), Cardiothoracic Surgery (P.M.), and Pharmacy (M.H.), Cleveland Clinic Foundation, Cleveland; the Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston (M.A.); the Cardiovascular Division, Brigham and Women's Hospital, Boston (J.J.); and the Harvard School of Public Health, Boston (R.Z.).

Address reprint requests to Dr. Calabrese at the Cleveland Clinic Foundation, 9500 Euclid Ave., Desk A-50, Cleveland, OH 44195, or at calabrl@ccf.org.


Related Letters:

Cardiac Transplantation in an HIV-1–Infected Patient
Morgan J. A., Bisleri G., Mancini D. M., Aberegg S. K., Calabrese L. H.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:1388-1389, Oct 2, 2003. Correspondence

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