Neurogenesis in the mammalian central nervous system was formerlyconsidered to end shortly after birth. We now know that neuralstem cells exist not only in the developing nervous system,but also in the nervous systems of all adult mammalian organisms,including humans.1 In the adult brain, new neurons are generatedprimarily in two regions: the subventricular zone and the subgranularzone1 of the hippocampal dentate gyrus. This neurogenesis occursunder normal conditions, and the generation of new neurons canincrease under pathologic conditions, such as the brain ischemiathat typifies a stroke.2 Whether newly formed neurons migrateto the . . . [Full Text of this Article]
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From the Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md.
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