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Previous Volume 348:2457-2463 June 12, 2003 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The sequencing of the human genome has revealed an almost complete "parts list" for the study of the genetic basis of disease.^1,2 The Online Mendelian Inheritance in Man data base lists more than 1000 human genes that have been implicated in specific diseases.³ It is likely that within a few years the causative lesion in most diseases that result from a mutation in a single gene will have been characterized, and geneticists are using sophisticated methods to track genes in polygenic diseases — that is, diseases caused by defects in more than a single gene.

Often, however, the rapid pace . . . [Full Text of this Article]

Yeast, Flies, Worms, and Fish

Identifying Genes Causing Human Disease in Model Organisms

Discovering New Genes

Defining Cellular Pathways

Toward Therapeutics

The Future

Source Information

From the Massachusetts General Hospital Cancer Center, Charlestown, Mass., and Harvard Medical School, Boston.

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