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Volume 348:2464-2466 June 12, 2003 Number 24
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Celecoxib versus Diclofenac and Omeprazole to Prevent Recurrent Ulcer Bleeding

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 by Graham, D. Y.
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 by Chan, F. K.L.
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To the Editor: In their report on the use of celecoxib as compared with diclofenac plus omeprazole to reduce the risk of recurrent ulcer bleeding in patients with arthritis, Chan et al. (Dec. 26 issue)1 state that the probability of recurrent bleeding was 4.9 percent in the celecoxib-treated patients (7 of 144) and 6.4 percent in those receiving the combination of diclofenac and omeprazole (9 of 143). These bleeding complications were considered by the adjudication committee to meet the criteria for recurrent ulcer bleeding, which was the primary end point. However, for the purposes of clinical practice, the eight other . . . [Full Text of this Article]




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