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Previous Volume 348:2466-2467 June 12, 2003 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The strong suggestion that aspirin has a chemopreventive effect was recently corroborated by Baron et al.¹ and Sandler et al.² (March 6 issue). Although the importance of the clinical outcome is clear, the molecular mechanism leading to the antineoplastic effect of aspirin remains controversial. Although the authors refer to the irreversible blockade of cyclooxygenase-2 (COX-2), this mechanism does not adequately explain the chemopreventive and pro-apoptotic effects of aspirin. For example, cells that do not express COX-2 also undergo apoptosis in response to nonsteroidal antiinflammatory drugs (NSAIDs).³

Nuclear factor-B has recently proved to be an interesting target . . . [Full Text of this Article]

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