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Previous Volume 348:2469-2470 June 12, 2003 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: With regard to the discussion by Friedmann et al. (March 20 issue)¹ of a mediastinal germ-cell tumor in an 18-year-old man, a malignant mediastinal germ-cell tumor in a young man should raise the suspicion of Klinefelter's syndrome (47,XXY). Patients with Klinefelter's syndrome have a relative risk of 66.7 for the development of a malignant mediastinal germ-cell tumor.² At least 8 percent of male patients with primary mediastinal tumors have Klinefelter's syndrome — 50 times the expected frequency.³ In a recent study,⁴ all 10 adolescents with a malignant mediastinal germ-cell tumor were male, and in approximately 50 percent . . . [Full Text of this Article]

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