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Previous Volume 348:2471-2472 June 12, 2003 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: The only treatment approved by the Food and Drug Administration for acute acetaminophen poisoning is a 72-hour protocol of oral N-acetylcysteine administration. Clinical experience suggests that this protocol may be excessive for many episodes of acute acetaminophen poisoning. Hepatotoxicity from such poisoning is preventable when intravenous administration of N-acetylcysteine is initiated within 8 to 10 hours after ingestion and continued for 20 hours.^1,2

We investigated the use of a 20-hour protocol of oral N-acetylcysteine for the management of acute ingestion of an acetaminophen product (except sustained-release preparations) between 1996 and 1999. The investigation was . . . [Full Text of this Article]

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• Betten, D. P., Vohra, R. B., Cook, M. D., Matteucci, M. J., Clark, R. F. (2006). Antidote use in the critically ill poisoned patient.. J Intensive Care Med 21: 255-277 [Abstract]  
• Fishbane, S., Durham, J. H., Marzo, K., Rudnick, M. (2004). N-Acetylcysteine In The Prevention Of Radiocontrast-Induced Nephropathy. J. Am. Soc. Nephrol. 15: 251-260 [Abstract] [Full Text]