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Volume 348:2579-2580 June 19, 2003 Number 25
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The Chromogranin–Secretogranin Family

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by Taupenot, L.
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To the Editor: Taupenot et al. (March 20 issue)1 state in their review article that the prognostic value of chromogranin A immunoreactivity in colorectal cancer has not been established. In fact, four out of five studies identify extensive neuroendocrine differentiation as an independent prognostic factor in Dukes' stage C colorectal cancer.2,3,4 Neuroendocrine differentiation also predicts a more aggressive clinical course in undifferentiated small-cell colorectal cancer.5


Hans Scherübl, M.D.
Patricia Grabowski, M.D.
Benjamin Franklin University Hospital
D-12200 Berlin, Germany
hans.scheruebl@medizin.fu-berlin.de

  1. Taupenot L, Harper KL, O'Connor DT. The chromogranin-secretogranin family. N Engl J Med 2003;348:1134-1149. [Free Full Text]
  2. Hamada Y, Oishi A, Shoji T, et al. Endocrine cells and prognosis in patients with colorectal carcinoma. Cancer 1992;69:2641-2646. [CrossRef][ISI][Medline]
  3. de Bruine AP, Wiggers T, Beek C, et al. Endocrine cells in colorectal adenocarcinomas: incidence, hormone profile and prognostic relevance. Int J Cancer 1993;54:765-771. [ISI][Medline]
  4. Grabowski P, Schindler I, Anagnostopoulos I, et al. Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer. Eur J Gastroenterol Hepatol 2001;13:405-411. [CrossRef][ISI][Medline]
  5. Grabowski P, Schonfelder J, Ahnert-Hilger G, et al. Expression of neuroendocrine markers: a signature of human undifferentiated carcinoma of the colon and rectum. Virchows Arch 2002;441:256-263. [CrossRef][ISI][Medline]
 
To the Editor: Taupenot et al. mention the accumulation of chromogranin A in the preamyloid plaques of Alzheimer's disease and its . . . [Full Text of this Article]



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