To the Editor: Rituximab targets CD20+ B cells. It is used increasinglyfor the treatment of B-cell non-Hodgkin's lymphoma, alone orin combination with cytotoxic agents.1,2 We report two patientswith non-Hodgkin's lymphoma in whom interstitial pneumonitisdeveloped after rituximab therapy.
Patient 1 was an 82-year-old woman who presented with bruising.Her blood count showed a hemoglobin concentration of 8.6 g perdeciliter, a white-cell count of 57,100 per cubic millimeter,a lymphocyte count of 44,900 per cubic millimeter, and a plateletcount of 32,000 per cubic millimeter. A bone marrow biopsy showeddiffuse infiltration with small BCL1+ and CD20+ . . . [Full Text of this Article]
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