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Inflammation of the blood-vessel wall is the common feature of a broad spectrum of clinical entities known collectively as the vasculitic diseases. Vasculitis can occur as a secondary process in association with another disease or exposure, or as a primary idiopathic process. The primary vasculitides have individual patterns of vascular involvement and histopathological characteristics that influence their clinical features, severity, and management. Although the vasculitic diseases are uncommon, they invite the interest of a wide range of medical disciplines because of the variety of their manifestations and the diagnostic and therapeutic challenges they pose.
In recent years, considerable progress has
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