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Previous Volume 348:473-474 January 30, 2003 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We disagree with the statement made by Brent and Birmaher (Aug. 29 issue)¹ that overdoses of selective serotonin-reuptake inhibitors (SSRIs) are rarely toxic. Although overdoses of an SSRI (as the single ingested agent) are rarely fatal,^2,3 toxicity sufficient to warrant specific treatment is well recognized, and ingestions of massive quantities may cause seizures and arrhythmias.

In addition, overdoses of a mixture of drugs that includes an SSRI are common. Simultaneous ingestion of an SSRI with other agents that affect serotonin release or reuptake, such as monoamine oxidase inhibitors, even in therapeutic doses, may produce serotonin toxicity.⁴ We . . . [Full Text of this Article]

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