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Volume 348:579-580 February 13, 2003 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In May 2002, the Women's Health Initiative (WHI) trial of daily combined therapy with estrogen and progestin was terminated early. The reason for stopping was an increased risk of breast cancer (and evidence of greater overall risk than benefit) in the hormone-therapy group. Far more surprising, however, was the associated increase in the risk of myocardial infarction. An expectation of coronary benefit had been a major reason for many women's decisions to use postmenopausal hormone therapy.

Earlier reports had failed to show improvement in cardiovascular outcomes in postmenopausal women with known cardiovascular disease who were treated with conjugated equine estrogen . . . [Full Text of this Article]

Source Information

From the Department of Medicine, Brigham and Women's Hospital, Boston (R.G.D.).

Dr. Solomon adjudicates end points for the Women's Health Initiative.

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