This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the author's clinicalrecommendations.
A 50-year-old black American has a blood pressure of 160/110mm Hg on repeated measurements. He is 9 kg (20 lb) overweight,has a family history of hypertension, and smokes one pack ofcigarettes daily. How should this patient be evaluated and treated?
The Clinical Problem
Hypertension (systolic pressure 140 mm Hg or diastolic pressure90 mm Hg) is present in one in four adults . . . [Full Text of this Article]
Strategies and Evidence
Evaluation
Treatment
Lifestyle Modifications
Treatment Goal for Blood Pressure
Choice of Antihypertensive Drugs
Other Considerations in the Choice of Therapy
Combination Therapy
Guidelines
Areas of Uncertainty
Conclusions and Recommendations
Source Information
From Weill Medical College of Cornell University and the Lang Research Center, New York Hospital Medical Center of Queens both in New York.
Fortuny, J., Sima, C., Bayuga, S., Wilcox, H., Pulick, K., Faulkner, S., Zauber, A. G., Olson, S. H.
(2009). Risk of Endometrial Cancer in Relation to Medical Conditions and Medication Use. Cancer Epidemiol. Biomarkers Prev.
18: 1448-1456
[Abstract][Full Text]
Cox, E. R., Halloran, D. R., Homan, S. M., Welliver, S., Mager, D. E.
(2008). Trends in the Prevalence of Chronic Medication Use in Children: 2002-2005. Pediatrics
122: e1053-e1061
[Abstract][Full Text]
Welty, F. K., Lee, K. S., Lew, N. S., Zhou, J.-R.
(2007). Effect of Soy Nuts on Blood Pressure and Lipid Levels in Hypertensive, Prehypertensive, and Normotensive Postmenopausal Women. Arch Intern Med
167: 1060-1067
[Abstract][Full Text]
Choi, H. K., Mount, D. B., Reginato, A. M.
(2005). Pathogenesis of Gout. ANN INTERN MED
143: 499-516
[Full Text]
Wong, T. Y., Mitchell, P.
(2004). Hypertensive Retinopathy. NEJM
351: 2310-2317
[Full Text]
Aurigemma, G. P., Gaasch, W. H.
(2004). Diastolic Heart Failure. NEJM
351: 1097-1105
[Full Text]
Steinberg, J. S., Sadaniantz, A., Kron, J., Krahn, A., Denny, D. M., Daubert, J., Campbell, W. B., Havranek, E., Murray, K., Olshansky, B., O'Neill, G., Sami, M., Schmidt, S., Storm, R., Zabalgoitia, M., Miller, J., Chandler, M., Nasco, E. M., Greene, H. L., the AFFIRM Investigators,
(2004). Analysis of Cause-Specific Mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study. Circulation
109: 1973-1980
[Abstract][Full Text]
Davrath, L. R., Goren, Y., Pinhas, I., Toledo, E., Akselrod, S.
(2003). Early autonomic malfunction in normotensive individuals with a genetic predisposition to essential hypertension. Am. J. Physiol. Heart Circ. Physiol.
285: H1697-H1704
[Abstract][Full Text]
Porat, G., Berend, K., August, P.
(2003). Initial Treatment of Hypertension. NEJM
349: 1090-1091
[Full Text]
(2003). Another Study of First-Line Antihypertensive Therapy. JWatch Gastroenterology
2003: 8-8
[Full Text]
(2003). Another Study of First-Line Antihypertensive Therapy. JWatch General
2003: 1-1
[Full Text]
Frohlich, E. D.
(2003). Treating Hypertension -- What Are We to Believe?. NEJM
348: 639-641
[Full Text]