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Previous Volume 348:681-682 February 20, 2003 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Creutzfeldt–Jakob disease is an unusual neurologic disorder, with a prevalence of approximately 1 case per million population, which is about 1/10,000 that of Alzheimer's disease. Creutzfeldt–Jakob disease has captured widespread attention, in part because of the recent epidemic of bovine spongiform encephalopathy ("mad cow disease") and the appearance of 139 cases of "new-variant" Creutzfeldt–Jakob disease, including two in North America. The disorder is due to neuronal degeneration resulting from the accumulation of a pathologic isoform (PrP^CJD) of the prion protein (PrP^C), a normal cellular protein. Eighty-five percent of cases of Creutzfeldt–Jakob disease are sporadic, with familial and iatrogenic . . . [Full Text of this Article]

Source Information

From the Department of Neurology, University of Colorado Health Sciences Center, and the Denver Veterans Affairs Medical Center — both in Denver.

This article has been cited by other articles:

• Brown, P. (2008). Transmissible spongiform encephalopathy in the 21st century: Neuroscience for the clinical neurologist. Neurology 70: 713-722 [Full Text]