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Correspondence
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Volume 348:860-863 February 27, 2003 Number 9
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The Olivieri Case

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 by Nathan, D. M.
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To the Editor: In their article on the dispute over the iron-chelating agent deferiprone (Oct. 24 issue),1 Nathan and Weatherall focus on the ethical implications for the relationships among scientists, their institutions, and industry. Their article ignores recent evidence on the safety and efficacy of the drug2,3,4,5 and does nothing to resolve the uncertainty that has made deferiprone unavailable to the majority of patients with thalassemia worldwide.

This very public controversy has generated fear, uncertainty, and doubt among such patients and their physicians, fomented mistrust among clinicians and researchers, and undermined patients' confidence in their doctors. Such doubts have been . . . [Full Text of this Article]




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