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Volume 349:3-4 July 3, 2003 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Vasculitis is defined by inflammation of the blood-vessel wall and forms the pathological foundation of a diverse group of individual disease entities. Among the primary systemic vasculitic diseases, Wegener's granulomatosis and microscopic polyangiitis share several common features, including pulmonary capillaritis, pauci-immune focal crescentic necrotizing glomerulonephritis, and circulating antineutrophil cytoplasmic antibodies (ANCA) that are specific for proteinase 3 or myeloperoxidase. Because both diseases are highly associated with ANCA, they are sometimes collectively referred to as ANCA-associated vasculitis. However, the presence of granulomatous inflammation in Wegener's granulomatosis represents a potentially important distinction between these two rare diseases, and it remains unclear whether . . . [Full Text of this Article]

Source Information

From the Immunologic Diseases Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.

Related Letters:

Maintenance Therapy for Vasculitis Associated with Antineutrophil Cytoplasmic Autoantibodies
Sanders J.-S. F., Slot M. C., Stegeman C. A., Jayne D., Rasmussen N.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:2072-2073, Nov 20, 2003. Correspondence

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