FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

A correction has been published: N Engl J Med 2003;349(6):620.

Previous Volume 349:60-72 July 3, 2003 Number 1 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Colussi, G. Related Article PubMed Citation

Cardiovascular disease, including stroke, is the leading cause of illness and death in the United States. There are an estimated 62 million people with cardiovascular disease and 50 million people with hypertension in this country.¹ In 2000, approximately 946,000 deaths were attributable to cardiovascular disease, accounting for 39 percent of all deaths in the United States.² Epidemiologic studies and randomized clinical trials have provided compelling evidence that coronary heart disease is largely preventable.³ However, there is also reason to believe that there is a heritable component to the disease. In this review, I highlight what we know now about genetic . . . [Full Text of this Article]

Lessons Learned from Monogenic Cardiovascular Disorders

Elevated Levels of Low-Density Lipoprotein Cholesterol and Coronary Artery Disease

Hypertension

Thrombosis and Hemostasis

Hypertrophic Cardiomyopathy

Cardiac Arrhythmias

Analysis of Complex Cardiovascular Traits

Gene Polymorphisms

Gene-Expression Profiling

Considerations for Molecular and Clinical Diagnosis

Source Information

From the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md.

Address reprint requests to Dr. Nabel at the National Heart, Lung, and Blood Institute, Bldg. 10/8C103, 10 Center Dr., Bethesda, MD 20892, or at enabel@nih.gov.

This article has been cited by other articles:

• Wilson, P. W.F. (2008). Progressing From Risk Factors to Omics. Circ Cardiovasc Genet 1: 141-146 [Full Text]  
• Dihazi, H., Koziolek, M. J., Sollner, T., Kahler, E., Klingel, R., Neuhoff, R., Strutz, F., Mueller, G. A. (2008). Protein adsorption during LDL-apheresis: proteomic analysis. Nephrol Dial Transplant 23: 2925-2935 [Abstract] [Full Text]  
• Edison, R. J., Berg, K., Remaley, A., Kelley, R., Rotimi, C., Stevenson, R. E., Muenke, M. (2007). Adverse Birth Outcome Among Mothers With Low Serum Cholesterol. Pediatrics 120: 723-733 [Abstract] [Full Text]  
• Heximer, S., Husain, M. (2007). A Candidate Hypertension Gene: Will SPON1 Hold Salt and Water?. Circ. Res. 100: 940-942 [Full Text]  
• Mani, A., Radhakrishnan, J., Wang, H., Mani, A., Mani, M.-A., Nelson-Williams, C., Carew, K. S., Mane, S., Najmabadi, H., Wu, D., Lifton, R. P. (2007). LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors. Science 315: 1278-1282 [Abstract] [Full Text]  
• Yamasaki, Y., Katakami, N., Sakamoto, K., Kaneto, H., Matsuhisa, M., Sato, H., Hori, M., Haneda, M., Kashiwagi, A., Tanaka, Y., Kawamori, R., Kuno, S.-i. (2006). Combination of multiple genetic risk factors is synergistically associated with carotid atherosclerosis in Japanese subjects with type 2 diabetes.. Diabetes Care 29: 2445-2451 [Abstract] [Full Text]  
• Seo, D., Ginsburg, G. S., Goldschmidt-Clermont, P. J. (2006). Gene Expression Analysis of Cardiovascular Diseases: Novel Insights Into Biology and Clinical Applications. J Am Coll Cardiol 48: 227-235 [Abstract] [Full Text]  
• Brusq, J.-M., Ancellin, N., Grondin, P., Guillard, R., Martin, S., Saintillan, Y., Issandou, M. (2006). Inhibition of lipid synthesis through activation of AMP kinase: an additional mechanism for the hypolipidemic effects of berberine. J. Lipid Res. 47: 1281-1288 [Abstract] [Full Text]  
• North, K. E., Goring, H. H. H., Cole, S. A., Diego, V. P., Almasy, L., Laston, S., Cantu, T., Howard, B. V., Lee, E. T., Best, L. G., Fabsitz, R. R., MacCluer, J. W. (2006). Linkage analysis of LDL cholesterol in American Indian populations: the Strong Heart Family Study. J. Lipid Res. 47: 59-66 [Abstract] [Full Text]  
• Parlakian, A., Charvet, C., Escoubet, B., Mericskay, M., Molkentin, J. D., Gary-Bobo, G., De Windt, L. J., Ludosky, M.-A., Paulin, D., Daegelen, D., Tuil, D., Li, Z. (2005). Temporally Controlled Onset of Dilated Cardiomyopathy Through Disruption of the SRF Gene in Adult Heart. Circulation 112: 2930-2939 [Abstract] [Full Text]  
• Mo, R., Chen, J., Grolleau-Julius, A., Murphy, H. S., Richardson, B. C., Yung, R. L. (2005). Estrogen Regulates CCR Gene Expression and Function in T Lymphocytes. J. Immunol. 174: 6023-6029 [Abstract] [Full Text]  
• Sanoudou, D., Vafiadaki, E., Arvanitis, D. A., Kranias, E., Kontrogianni-Konstantopoulos, A. (2005). Array lessons from the heart: focus on the genome and transcriptome of cardiomyopathies. Physiol. Genomics 21: 131-143 [Abstract] [Full Text]  
• Hunt, C E (2005). Gene-environment interactions: implications for sudden unexpected deaths in infancy. Arch. Dis. Child. 90: 48-53 [Abstract] [Full Text]  
• Lio, D, Candore, G, Crivello, A, Scola, L, Colonna-Romano, G, Cavallone, L, Hoffmann, E, Caruso, M, Licastro, F, Caldarera, C M, Branzi, A, Franceschi, C, Caruso, C (2004). Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease. J. Med. Genet. 41: 790-794 [Full Text]  
• Lusis, A. J., Fogelman, A. M., Fonarow, G. C. (2004). Genetic Basis of Atherosclerosis: Part I: New Genes and Pathways. Circulation 110: 1868-1873 [Full Text]  
• Melo, L.G, Gnecchi, M, Pachori, A.S, Wang, K, Dzau, V.J (2004). Gene- and cell-based therapies for cardiovascular diseases: current status and future directions. Eur Heart J Suppl 6: E24-E35 [Abstract] [Full Text]  
• Lanfear, D. E., Marsh, S., Cresci, S., Shannon, W. D., Spertus, J. A., McLeod, H. L. (2004). Genotypes associated with myocardial infarction risk are more common in African Americans than in European Americans. J Am Coll Cardiol 44: 165-167 [Abstract] [Full Text]  
• Colussi, G., Hall, S. W., Nabel, E. G. (2003). Cardiovascular Genomics. NEJM 349: 1387-1388 [Full Text]  
• Guttmacher, A. E., Collins, F. S. (2003). Welcome to the Genomic Era. NEJM 349: 996-998 [Full Text]