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Case Records of the Massachusetts General Hospital
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Volume 349:1076-1082 September 11, 2003 Number 11
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Case 28-2003 — A 51-Year-Old Premenopausal Woman with Newly Diagnosed Breast Cancer and a Strong Family History of Breast Cancer
Paula D. Ryan, M.D., Ph.D., Daniel A. Haber, M.D., Ph.D., Kristen M. Shannon, M.S., C.G.C., Barbara L. Smith, M.D., Ph.D., and Melinda J. Fan, M.D.

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Presentation of Case

A 51-year-old, premenopausal woman came to this hospital with a newly diagnosed breast carcinoma and a strong family history of breast cancer.

Three months earlier, on physical examination at another institution, a mass in the upper outer quadrant of the right breast had been found. Examination of a fine-needle aspirate showed atypical ductal cells. An excisional biopsy, also performed elsewhere, revealed a 0.2-cm invasive lobular carcinoma (stage T1a), with ductal carcinoma in situ and lobular carcinoma in situ (Figure 1).

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Figure 1. Biopsy Specimen of the Right Breast (Hematoxylin and Eosin).

There is a 0.2-cm invasive carcinoma (Panel A, x. . . [Full Text of this Article]

 
Pathological Discussion

Management Discussion

Pathological Diagnosis


Source Information

From the Gillette Center for Women's Cancer (P.D.R., B.L.S.), the Division of Medical Oncology (P.D.R.), the Center for Cancer Risk Analysis (P.D.R., D.A.H., K.M.S.), the Cancer Center (D.A.H.), the Division of Surgical Oncology (B.L.S.), and the Department of Pathology (M.J.F.), Massachusetts General Hospital; and the Departments of Medicine (P.D.R., D.A.H.), Surgery (B.L.S.), and Pathology (M.J.F.), Harvard Medical School — all in Boston.


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