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Volume 349:1088-1089 September 11, 2003 Number 11
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Puberty and Genetic Susceptibility to Breast Cancer

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 by Hamilton, A. S.
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To the Editor: Hamilton and Mack (June 5 issue)1 note that in twins with the greatest genetic susceptibility to breast cancer, the strongest influence on age at diagnosis was "earlier puberty." They used the age at which the breasts developed as an indicator of the onset of puberty. We recently reported a study of 443 girls followed from the ages of 9 and 10 years who had either breast development or pubic-hair development, but not both, at the onset of puberty.2 The age at the onset of puberty was similar in the two groups of girls. Those who had breast . . . [Full Text of this Article]


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