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Previous Volume 349:1190-1191 September 18, 2003 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: To determine whether itraconazole prevents fungal infections, Gallin et al. (June 12 issue)¹ used treatment alternation as the basis for inference but did not consider that the group with greater exposure would, by chance alone, tend to have more events (severe fungal infections) than the other group. Of the 39 patients, 21 received placebo during odd years. Using as the base not 0.5 but rather the probability that an event occurs during exposure to the treatment received during odd years increases the P value to somewhat more than 0.102, since P = 2[(0.5)⁵ + (5)(0.5)⁸] = . . . [Full Text of this Article]

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