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Volume 349:1287-1288 September 25, 2003 Number 13
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Bortezomib in Multiple Myeloma

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 by Richardson, P. G.
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To the Editor: Proteasome inhibition is an interesting approach to the treatment of multiple myeloma, but the results of the study by Richardson et al. (June 26 issue)1 are difficult to evaluate. Although the authors claim an overall response rate of 35 percent, more than two thirds of these responses were either "partial" or "minimal" — terms the authors failed to define. They mention that some patients actually had an increase in the levels of monoclonal immunoglobulin (but do not include this category in Table 2 of their article). It would also be helpful to know what the investigators mean . . . [Full Text of this Article]




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