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Volume 349:1288-1290 September 25, 2003 Number 13
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Prednisone for Chronic Obstructive Pulmonary Disease

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by Aaron, S. D.
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To the Editor: We have reservations about the interpretation of the study by Aaron et al. of oral prednisone after outpatient treatment of chronic obstructive pulmonary disease (COPD) (June 26 issue)1 because of concern about the study design and statistical analysis. Aaron et al. state that prednisone significantly reduced the rate of relapse at 30 days (27 percent, vs. 43 percent with placebo; P=0.05) and that the relative risk of relapse after prednisone therapy was 0.63 (95 percent confidence interval, 0.40 to 1.01). We believe that these statements are misleading, given that the P value is 0.05 and that the . . . [Full Text of this Article]



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