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Correspondence
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Volume 349:1294-1295 September 25, 2003 Number 13
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Guidelines for Xenotransplantation

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To the Editor: Xenotransplantation provides a potentially promising solution to the shortage of human organs and tissues and offers advantages over other approaches. The development of genetically modified pigs that lack expression of the {alpha}-1,3-galactosyltransferase target of humoral rejection is particularly promising.1 Although the possibility of introducing new infections from source animals into humans has been a concern,2 such transmission has apparently not occurred in xenotransplantations to date.3 Nevertheless, this theoretical risk mandates caution in clinical xenotransplantation. Consequently, considerable effort has been made in several countries to develop guidelines for the husbandry of source animals and for the monitoring of . . . [Full Text of this Article]



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