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Volume 349:1385-1387 October 2, 2003 Number 14
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Dalteparin Compared with an Oral Anticoagulant for Thromboprophylaxis in Patients with Cancer

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 by Bick, R. L.
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 by Lee, A. Y.Y.
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To the Editor: Lee and colleagues (July 10 issue)1 provide strong and pertinent data indicating the benefit of prolonged treatment with low-molecular-weight heparin for the prevention of recurrent venous thromboembolism in patients with cancer. Nevertheless, among the patients who received an oral anticoagulant, the international normalized ratio (INR) was above the therapeutic range 24 percent of the time. This could be a source of bias in evaluating the effect of the coumarin derivative. In addition, we wonder whether the authors found that the number of patients with clinically relevant thrombocytopenia was higher after long-term treatment with low-molecular-weight heparin than it . . . [Full Text of this Article]




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