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Previous Volume 349:1476-1479 October 9, 2003 Number 15 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Elfenbein, G. J. Related Article by Tallman, M. S. Related Article by Rodenhuis, S. PubMed Citation

To the Editor: The conclusion drawn by Rodenhuis et al. (July 3 issue)¹ — that high-dose therapy improves relapse-free survival among patients with 10 or more positive nodes — is untenable. The authors failed to apply the method specified in their Statistical Analysis section — namely, the use of tests for interaction to evaluate differences in the treatment effect within subgroups. Such analysis does not provide good evidence that there is greater benefit for patients with 10 or more positive nodes than for those with fewer than 10. The P values in individual subgroups are unimportant; the P value for . . . [Full Text of this Article]

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