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A 37-year-old woman was referred to the colposcopy clinic because of two Papanicolaou smears showing atypical squamous cells of undetermined significance (ASC-US).
One and two years previously, the patient had had Papanicolaou smears that were reported to be normal. Six months before referral, a routine pelvic examination revealed no abnormalities. A Papanicolaou smear at that time was interpreted as revealing ASC-US. The patient was reexamined three months later, and another Papanicolaou smear was again interpreted as showing ASC-US.
The patient (gravida 5, para 4) had had one spontaneous first-trimester abortion. She was a native of El Salvador but had resided
Differential Diagnosis
Pathological Discussion
Discussion of Management
Pathological Diagnosis
Source Information
From the Gillette Center for Women's Cancers and the Division of Gynecologic Oncology (A.G.) and the Department of Pathology, Cytopathology Division (D.C.W.), Massachusetts General Hospital; and the Department of Obstetrics, Gynecology, and Reproductive Biology (A.G.) and the Department of Pathology (D.C.W.), Harvard Medical School.
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