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Volume 349:1575-1576 October 16, 2003 Number 16
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Case 25-2003: Congenital Cytomegalovirus Infection

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by Modlin, J. F.
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To the Editor: Participants in the discussion of the differential diagnosis in Case 25-2003 (Aug. 14 issue),1 involving a neonate with intrauterine growth retardation, hepatosplenomegaly, thrombocytopenia, and periventricular calcifications, fail to mention lymphocytic choriomeningitis virus infection.2 Congenital lymphocytic choriomeningitis virus infection has been diagnosed in more than 50 infants.3,4 Periventricular calcifications and chorioretinitis occur in approximately 90 percent of such neonates. Microcephaly or macrocephaly (commonly) and hepatosplenomegaly and petechiae (rarely) have also been noted. Lymphocytic choriomeningitis virus is an arenavirus asymptomatically shed by chronically viremic mice and variably symptomatic golden hamsters. It is thus a potentially preventable zoonotic infection and . . . [Full Text of this Article]



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