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Previous Volume 349:1589-1592 October 23, 2003 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The ontogeny of human gonadotropin secretion is remarkable for surges in pulsatile secretion during the neonatal period and in early childhood, followed by a period of quiescence (the so-called juvenile pause), which reflects the inhibition of the generation of neurosecretory pulses of gonadotropin-releasing hormone by the hypothalamus. Negative feedback by means of gonadal steroids is one inhibitory mechanism, since agonadal infants have heightened gonadotropin secretion as compared with children who have intact gonads. On the other hand, gonadotropin secretion in agonadal children is suppressed during the juvenile pause, which suggests the presence of an intrinsic, hormone-independent inhibitory mechanism in the . . . [Full Text of this Article]

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From the Division of Genetics (D.R.B.) and the Division of Endocrinology, Diabetes, and Hypertension (R.G.D.), Department of Medicine, Brigham and Women's Hospital; and Harvard Medical School (D.R.B., R.G.D.) — both in Boston.

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