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Editorial
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Volume 349:1855-1857 November 6, 2003 Number 19
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Letrozole after Tamoxifen for Breast Cancer — What Is the Price of Success?
John Bryant, Ph.D., and Norman Wolmark, M.D.

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 by Goss, P. E.
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In this issue of the Journal, Goss et al.1 report results from a trial that will have a considerable effect on the treatment of early-stage breast cancer. The study was led by the National Cancer Institute of Canada Clinical Trials Group and was a joint effort of the North American Intergroup and the Breast International Group. These organizations are to be commended for a well-conceived and well-conducted clinical trial. Their work is an excellent example of the way in which clinical-trial organizations can work together efficiently and expeditiously to investigate clinical questions of common interest.

Previous trials have shown that . . . [Full Text of this Article]


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From the National Surgical Adjuvant Breast and Bowel Project (J.B., N.W.); the Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh (J.B.); and the Department of Human Oncology, Allegheny General Hospital (N.W.) — all in Pittsburgh.

This editorial was published at www.nejm.org on October 9, 2003.


Related Letters:

Letrozole in Breast Cancer
Buzdar A. U., Hietanen P., Mäkelä M., Shahab N., Harris S. R., Hellman S., Hellman D., Goss P. E., Ingle J. N., Pater J. L., Bryant J., Wolmark N., Burstein H. J.
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N Engl J Med 2004; 350:727-730, Feb 12, 2004. Correspondence

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