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Previous Volume 349:1860-1865 November 6, 2003 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In 1995, Harold E. Varmus, who was then the director of the National Institutes of Health (NIH), convened the NIH Director's Panel on Clinical Research. The panel was charged with making recommendations to foster the NIH's support of clinical research, a field that was pervaded by discouragement and believed to be in jeopardy.^1,2,3,4 The panel met between July 1995 and November 1997, when it issued a series of recommendations.^2,5 In this article, we review these recommendations, inventory the changes made within the NIH and in clinical-research portfolios within the private sector since 1995, and assess the effects of these changes.

Definitions and Recommendations

. . . [Full Text of this Article]

Inventory of Changes and Evaluation of Their Effects

Spending for Clinical Research

The Clinical-Research Portfolio

First-Time Applicants and Their Renewal Rates

New Clinical-Research Grants

Reorganization of Study Sections

Training in Clinical Research

Educational-Loan Relief

General Clinical-Research Centers

Conclusions

Source Information

From the Department of Pediatric Oncology, Dana–Farber Cancer Institute, Boston (D.G.N.); and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas (J.D.W.).

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