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Volume 349:107-109 July 10, 2003 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple sclerosis is characterized by recurrent neurologic events (clinical relapses) that are attributable to multifocal lesions within the central nervous system. Lesions referred to as "active plaques" are characterized by the presence of inflammation and active myelin degradation and phagocytosis. These lesions have been subtyped according to the relative presence of immunoglobulin (i.e., antibodies) and according to whether the primary injury is directed at the myelin itself or its cell of origin, the oligodendrocyte. Pathological and magnetic resonance imaging (MRI) studies show that axonal injury occurs early in the course of disease. The potential for remyelination is greatest at this . . . [Full Text of this Article]

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From the Montreal Neurological Institute, McGill University, Montreal.

Related Letters:

Antimyelin Antibodies in Multiple Sclerosis
Maguire G. A., Mantegazza R., Chaudhuri A., Behan P. O., Berger T., Reindl M.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:2269-2271, Dec 4, 2003. Correspondence

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